Effective CO2 insufflation over a surgical wound can displace available air, contributing to CO2 reducing infection. Since CO2 is 25 times more soluble in blood and tissue than air (at 37 degrees Celsius), it enhances CO2 surgical applications, particularly when utilizing devices like the Medtronic gas diffuser. Additionally, arterial CO2 emboli, such as those encountered during deairing the chest cavity, are much better tolerated than air emboli, further supporting its role in CO2 wound healing.