Inhaled CO2 to Reduce Lung Ischemia and Reperfusion Injuries: Moving Towards Clinical
Translation?
Claire H. Masterson, PhD1,2
Daniel O’Toole, PhD1,2
John G. Laffey, MD, MA, BSc, FCAI1,2,3
RECEIVED FROM:
1 Anaesthesia, School of Medicine, National University of Ireland, Galway, Ireland.
2 Regenerative Medicine Institute (REMEDI) at CÚRAM Centre for Research in Medical Devices,
Biomedical Sciences Building, National University of Ireland Galway, Galway, Ireland.
3 Department of Anaesthesia and Intensive Care Medicine, Galway University Hospitals, Galway, Ireland.
American Thoracic Society 2021
"This study demonstrates a clear benefit of inspired CO2 in a ligated pulmonary artery model, although the intervention is at an early timepoint. It adds to a growing body of work accumulated to this point demonstrating the therapeutic potential of inspired CO2 for ischemia/reperfusion injuries. This possible therapeutic option is
relatively simple to implement and test, has few obvious side-effects and critical care physicians are very familiar with managing hypercapnia in the critically ill patients."